As the demand for additional services became apparent, Little Red Door volunteers established a loan cupboard stocked with sickroom supplies and dressings. In 1950, the need for additional funds to support the program resulted in Little Red Door becoming affiliated with the Community Fund, today known as United Way of Central Indiana. Three years later Little Red Door was issued a non-profit charter as the Marion County Cancer Society Inc.
Continued growth of services resulted in the agency moving to the first floor of the Cole Building at 730 East Washington Street in 1963 and then moving a second time in 1968 to its present location at 1801 North Meridian Street. These moves enabled the agency to improve continuity and stability for the services provided.
After 50 years of using the unofficial name Little Red Door, the organization formally changed its name to Little Red Door Cancer Agency Inc. in 1995 and unveiled its current logo.

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